PhD Candidate within Molecular Medicine

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At NTNU, 9,000 employees and 43,000 students work to create knowledge for a better world.

You will find more information about working at NTNU and the application process here.

About the job

We have vacancy for one PhD candidate at the Otterlei group at the Department of Clinical and Molecular Medicine. The project addresses the need for new antibiotics with novel mechanisms of action and new treatment regimens to handle the emerging antimicrobial resistance (AMR).

Based on knowledge of peptides with antibacterial activities and conserved mechanisms for mutagenesis, we have designed synthetic peptides with strong anti-mutagenic, antibacterial and anti-biofilm activities. These peptides interfere with DNA translesion synthesis (i.e. mutagenesis), bacterial replication, and cellular signalling, and is targeting the bacterial DNA sliding clamp, the b-clamp. The project specifically focuses on development of second-generation antibacterial peptides. This project is part of a multidisciplinary collaboration project (TAMiR - NTNU) between two faculties at NTNU, University of Oslo / Oslo University Hospital and University of Copenhagen and cover competences from basic molecular microbiology, chemical synthesis and structural biology/modelling, bioinformatics, cell biology and immunology/infectious diseases.

The PhD candidate will study antimicrobial activities of the peptides using several different methods used in medical microbiology and evaluate the toxicity of the peptides in cell line based assays as well as initial toxicity studies in animals.

Required selection criteria

The PhD-position's main objective is to qualify for work in research positions. The qualification requirement is that you have completed a master’s degree or second degree (equivalent to 120 credits) with a strong academic background in biochemistry, microbiology, molecular and cell biology or equivalent education with a grade of B or better in terms of NTNU’s grading scale. If you do not have letter grades from previous studies, you must have an equally good academic foundation. If you are unable to meet these criteria you may be considered only if you can document that you are particularly suitable for education leading to a PhD degree.

Master's students can apply, but the master's degree must be obtained and documented by the end of june 2024.

The appointment is to be made in accordance with Regulations on terms of employment for positions such as postdoctoral fellow, Phd candidate, research assistant and specialist candidate and Regulations concerning the degrees of Philosophiae Doctor (PhD) and Philosodophiae Doctor (PhD) in artistic research national guidelines for appointment as PhD, post doctor and research assistant

Preferred selection criteria

• Good computer skills/data processing skills,
• Good communications skills
• Good written and oral English language skills
• Felasa C certificate or intention to take this

Personal characteristics

• A strong interest in medical research
• Ability to work in teams
• Ability to work independently

In the evaluation of which candidate is best qualified, emphasis will be placed on education, experience and personal suitability.

We offer

• exciting and stimulating tasks in a strong international academic environment
• an open and inclusive work environment with dedicated colleagues
• favourable terms in the Norwegian Public Service Pension Fund
• employee benefits

Salary and conditions

As a PhD candidate (code 1017) you are normally paid from gross NOK 532 200 per annum before tax, depending on qualifications and seniority. From the salary, 2% is deducted as a contribution to the Norwegian Public Service Pension Fund.

The period of employment is 3 years.

Appointment to a PhD position requires that you are admitted to the PhD programme in Medicine and Health Sciences within three months of employment, and that you participate in an organized PhD programme during the employment period.

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The engagement is to be made in accordance with the regulations in force concerning State Employees and Civil Servants, and the acts relating to Control of the Export of Strategic Goods, Services and Technology. Candidates who by assessment of the application and attachment are seen to conflict with the criteria in the latter law will be prohibited from recruitment to NTNU. After the appointment you must assume that there may be changes in the area of work.

It is a prerequisite you can be present at and accessible to the institution on a daily basis.

About the application

The application and supporting documentation to be used as the basis for the assessment must be in English.

Publications and other scientific work must be attached to the application. Please note that your application will be considered based solely on information submitted by the application deadline. You must therefore ensure that your application clearly demonstrates how your skills and experience fulfil the criteria specified above.

The application must include:

• CV and certificates
• transcripts and diplomas for bachelor's and master's degrees. If you have not completed the master's degree, you must submit a confirmation that the master's thesis has been submitted.
• A copy of the master's thesis. If you recently have submitted your master's thesis, you can attach a draft of the thesis. Documentation of a completed master's degree must be presented before taking up the position.
• Name and contact information of three referees
• If you have publications or other relevant research work

If all, or parts, of your education has been taken abroad, we also ask you to attach documentation of the scope and quality of your entire education, both bachelor's and master's education, in addition to other higher education. Description of the documentation required can be found here. If you already have a statement from NOKUT, please attach this as well.

We will take joint work into account. If it is difficult to identify your efforts in the joint work, you must enclose a short description of your participation.

NTNU is committed to following evaluation criteria for research quality according to The San Francisco Declaration on Research Assessment - DORA.

General information

Working at NTNU

NTNU believes that inclusion and diversity is our strength. We want to recruit people with different competencies, educational backgrounds, life experiences and perspectives to contribute to solving our social responsibilities within education and research. We will facilitate for our employees’ needs.

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The city of Trondheim is a modern European city with a rich cultural scene. Trondheim is the innovation capital of Norway with a population of 200,000. The Norwegian welfare state, including healthcare, schools, kindergartens and overall equality, is probably the best of its kind in the world. Professional subsidized day-care for children is easily available. Furthermore, Trondheim offers great opportunities for education (including international schools) and possibilities to enjoy nature, culture and family life and has low crime rates and clean air quality.

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As an employee at NTNU, you must at all times adhere to the changes that the development in the subject entails and the organizational changes that are adopted.

A public list of applicants with name, age, job title and municipality of residence is prepared after the application deadline. If you want to reserve yourself from entry on the public applicant list, this must be justified. Assessment will be made in accordance with current legislation. You will be notified if the reservation is not accepted.

If you have any questions about the position, please contact Professor Marit Otterlei, telephone +47 72573075, email marit.otterlei@ntnu.no. If you have any questions about the recruitment process, please contact Vebjørn F. Andreassen, e-mail: vebjorn.andreassen@ntnu.no

If you think this looks interesting and in line with your qualifications, please submit your application electronically via jobbnorge.no with your CV, diplomas and certificates attached. Applications submitted elsewhere will not be considered. Upon request, you must be able to obtain certified copies of your documentation.

Application deadline: 10.06.2024