Postdoctoral Fellow in Computational Biology & Gene Regulation

Centre for Molecular Medicine Norway (NCMM), Nordic EMBL Partnership for Molecular Medicine

The Computational Biology & Gene Regulation group led by Anthony Mathelier at the NCMM, a part of the Nordic EMBL Partnership for Molecular Medicine, and the Genomic Regulation for Precision Cancer Medicine Lab led by Alfonso Urbanucci at the Institute for Cancer Research, Oslo University Hospital are seeking an ambitious and highly motivated Postdoctoral Fellow for a two-year position starting as early as possible in 2024.

Position Description

The selected candidate will contribute to the projects “CRÊPE: Cis-regulatory elements for prostate carcinogenesis”, which is funded through the joint postdoctoral scheme of NCMM, and “DiSC-Seq2.0: Understanding metastatic potential and biology of prostate cancer at the single cell level”, which is funded by the Norwegian Cancer Society. The candidate will study gene expression deregulation promoting prostate cancer using in house large-scale CRISPRi screening in vitro and clinical gene expression patterns derived from single cell data associated with patients outcome. The postdoctoral fellow will be co-supervised by Drs. Alfonso Urbanucci, Anthony Mathelier, and Roza Berhanu Lemma.

Requirements

The ideal candidate should meet the following criteria:

• Ph.D. in Computational Biology, Bioinformatics, or a related field obtained in the last 5 years or soon to be obtained.
• Possess strong programming skills.
• Experience in machine learning.
• Experience with computational genomics data analysis.
• At least one first author manuscript published or accepted in an international peer-reviewed journal at the time of application (exception can be made for 1st authorship in a preprint on a relevant topic).
• Documented ability to communicate science.
• Ability to collaborate with researchers from different fields and at different career stages.
• Willingness to be part of a team to share knowledge and skills.
• Excellent written and verbal communication skills in English.

Advantageous skills

• Understanding of gene transcription regulation.
• Basic understanding of cancer development and progression in the context of different omics levels.
• Understanding of statistical analysis in biomarker discovery.
• Track record of developing reproducible computational pipelines.
• Experience with CRISPRi screening data analysis.
• Experience with single cell data analysis.
• Experience in deep learning.

What we offer

• A salary of NOK 575 400 - 646 000 per annum depending on qualifications in position as Postdoctoral Research Fellow (position code 1352)
• A role within ambitious and multi-disciplinary teams that combine the strengths of both experimental and computational sciences, aimed at delivering high-impact research.
• Attractive welfare benefits including a generous pension agreement.
• A family-friendly environment in Oslo, known for its high quality of life, rich cultural scene, and abundant opportunities for outdoor activities.

Application Procedure

Applicants should include (1) a cover letter outlining motivations, career goals, relevant experience, and research interests, (2) a CV with list of publications, and (3) two-three referees contact information. These should be uploaded as a single PDF document in the electronic recruiting system. All documents should be in English.

It is expected that the successful candidate will be able to complete the project in the course of the period of employment.

Formal regulations

Please see the guidelines and regulations for appointments to Postdoctoral fellowships at the University of Oslo.

No one can be appointed for more than one Postdoctoral Fellow period at the University of Oslo.

According to the Norwegian Freedom of Information Act (Offentleglova) information about the applicant may be included in the public applicant list, also in cases where the applicant has requested non-disclosure.

Inclusion and diversity are a strength. The University of Oslo has a personnel policy objective of achieving a balanced gender composition. Furthermore, we want employees with diverse professional expertise, life experience and perspectives.

If there are qualified applicants with disabilities, employment gaps or immigrant background, we will invite at least one applicant from each of these categories to an interview.

Contact information

Inquiries about the position can be directed to Anthony Mathelier

About the application: ninam@ncmm.uio.no