Special Engineer in breast cancer, single cell RNA sequencing and spatial transcriptomic
- Arbeidsgiver
- Oslo universitetssykehus HF
- Stillingstittel
- Special Engineer in breast cancer, single cell RNA sequencing and spatial transcriptomic
- Frist
- 10.03.2024
- Ansettelsesform
- Engasjement
A 2-year position as special engineer (spesialingeniør) is available at the Department of Medical Genetics, Oslo University Hospital in the period 1.April 2024 - 31.March 2026.
The Department of Medical Genetics at Oslo University Hospital is Norway’s largest medical genetics department with over 200 employees. The department is responsible for diagnostics of rare and inherited diseases, and runs a national research infrastructure for high-throughput DNA sequencing at the Norwegian Consortium for Sequencing and Personalized Medicine (www.norseq.org). The research section in the department has 7 research groups (www.ous-research.no/meg/) working in various fields of medical genetics, including breast cancer, the genetics of autoimmune, neurological, cardiovascular and psychiatric disorders, epigenetics causes of disease, as well as groups focusing on bioinformatics.
The position will be associated with the ‘breast cancer heterogeneity and oncoimmunology project group (https://www.ous-research.no/tekpli) and is financed by the Norwegian Cancer Society through the project: "Empowering Precision Oncology: Insights into Tumor-Host Interactions to Personalize Breast Cancer Treatment".
The lab has longstanding collaborations with oncologists at Oslo University Hospital (OUH) and Akershus University Hospital (Ahus) and conducts translational research in numerous clinical trials. Currently, the laboratory employs state-of-the-art technologies and methods on both fresh and archival breast tumors. Over the past 2-3 years, we have successfully applied various techniques to profile single cells within breast tumors, along with conducting spatial omics analyses.
Well established methods in the lab are single cell RNA sequencing (scRNA-seq) and spatial transcriptomics (ST) which we perform at different time points of neoadjuvant therapy. Currently, the major focus of the lab is to use these methods to understand which exact cell types / phenotypes are sensitive or resistant to therapies and to characterize how the tumor microenvironment may be associated with response to cancer therapies.
Work tasks
The main aims of the special engineer will be to perform scRNA-seq and spatial transcriptomics based on established protocols in the lab, and to participate in the development of new methods which we believe will help to better understand breast cancer evolution under treatment pressure.Qualifications
We are looking for a special engineer who is highly motivated, well organized and dynamic with creative thinking.
- MSc with a topic in one of the following areas is required: molecular biology, cellular biology, biotechnology or similar.
- Working proficiency in molecular and cellular biology methods is required.
- Experience in one of the following topics is advantageous: library preparation for next-generation sequencing, single cell RNA sequencing, spatial transcriptomics.
Personal skills
The right candidate:
- Is a highly motivated and dynamic person.
- Is well organized with creativethinking.
- Has high intrinsic motivation and scientific curiosity.
- Has excellent oral and written English communication skills.
We offer
- A full-time contract for two years with the opportunity of an extension, depending on funding.
- Access to state-of-the-art technologies and methodologies.
- Salary in accordance with experience.
- Flexible hours.
- A stimulating (international, multidisciplinary) research environment where quality, professionalism and team spirit are encouraged.
- A multidisciplinary environment.
- The ability to work on scientifically exceptional and high impact, state-of-the-art projects.
- The opportunity to be part of a young and dynamic team and to provide a meaningful contribution to cancer research.
- Rigorous research training and supervision.
How to apply
All applications must include:
- A presentation letter describing your motivation.
- A full CV including contact details, a list of your publications (if any).
- Transcripts and diplomas for bachelor's and master's degrees. If you have not completed the master's degree, you must submit confirmation that the master's thesis has been submitted.
- Name and contact information of 2-3 referees.
- Only applications through web-cruiter will be taken into account.
Om arbeidsgiveren
Sammen med pasienten utvikler vi morgendagens behandling
Oslo universitetssykehus med våre 25 000 medarbeidere skal være en lærende og skapende organisasjon med evne til å tenke nytt. Vi skal ha en ledende rolle i utvikling av forskning og innovasjon, samt utvikling av morgendagens helsetjeneste, medisinsk behandling og presisjonsmedisin. Hos oss finner du noen av landets ledende eksperter innen sine fagfelt, og her blir du en del av Norges største helsefaglige arbeidsplass. Et inkluderende arbeidsmiljø preget av åpenhet og respekt er svært viktig for oss. Uansett hva du jobber med vil du få muligheten til å utvikle deg og benytte din kompetanse på et sted hvor det virkelig teller.
- Sektor
- Offentlig
- Sted
- Kirkeveien 166, 0455 Oslo
- Bransje
- Forskning, utdanning og vitenskap,
- Helse og omsorg,
- Farmasi og legemiddel
- Stillingsfunksjon
- Helsepersonell,
- Ingeniør,
- Forskning/Stipendiat/Postdoktor
- Arbeidsspråk
- Engelsk
Nøkkelord
Special engineer, Biologi, Cancer, Research, Science
Spørsmål om stillingen
- Kontaktperson
- Xaver Tekpli
- Stillingstittel
- project leader
Kirkeveien 166, 0455 Oslo