2 Postdoc research fellowships in cancer immunology
- Oslo universitetssykehus HF
- Postdoc research fellowships
Two three-year full time Postdoc Research Fellowships in cancer immunology is available at the Department of Pathology, Oslo University Hospital – Rikshospitalet.
The Department of Pathology is one out of seven departments within the Division of Laboratory medicine (https://www.youtube.com/watch?v=pf4ZtMsryzk). It is the largest pathology department in Norway, with close to 300 employees. The Department has a very strong research section that is organized in seven research groups, which integrate university and hospital research activities. Current research topics address cancer, immunopathology, inflammation and neurodegenerative diseases.
Oslo University Hospital is a workplace with great diversity. We believe this is essential to perform the tasks required of us. Therefore, we pursue diversity among our job applicants and encourage everyone to apply regardless of who you are and what background you have. Oslo University Hospital is a highly specialised hospital in charge of extensive regional and local hospital assignments and the provision of high quality services for the citizens of Oslo. The hospital also has a nationwide responsibility for a number of national and multi-regional assignments and has several national centres of competence.
The positions is available from early 2022 with a flexible start from February to June 2022. The positions will be located in the laboratory of Professor Jahnsen (website: https://jahnsenlab.org). The aim of the project is to understand the role of the immune tumour environment in colorectal cancer.
The Jahnsen team has a very strong record in human mucosal immunology research and has over the last few years built very strong competence in bioinformatics for single cell multiomics analysis. In this project we will collaborate with internationally and nationally leading research groups within cancer biology and cancer genetics, bioinformatics, oncology, and gastrointestinal surgery. We will apply an integrated approach combining high throughput single-cell technologies with advanced imaging techniques including spatial transcriptomics. We have access to a unique well characterized clinical biopsy material from several thousand colorectal patients. We will also perform functional in vitro studies and culture complex organoids to study tumour-immune cell interactions in a near in vivo situation.
The successful candidates will work closely with bioinformaticians in the group and the project will use advanced single cell technologies combining scRNA-seq/TCR-seq/BCR-seq with epigenomics (scATAC-seq etc). Moreover, the project will establish methods to integrate multiomics with spatial transacriptomics to analyze the immune tumour microenvironment in time and space at the single cell level.
The candidates will:
- . Isolate single cells from cancer tissue for high throughput single-cell analyses and functional studies
- . Culture tumour organoids from colorectal cancer with both epithelial cells, stromal cells and immune cells to study the immune tumor microenvironment and test immunotherapeutic targets in as near clinical setting
- . Perform spatial transcriptomics in combination with multispectral multi-color immunostaining to study the immune tumor microenvironment in situ
The project will be supervised by Dr. Jahnsen, Dr. Bækkevold and Dr. Domanska (bioinformatics) – all working in the Jahnsen group. The lab consists of 15 people all working on different aspect of mucosal immunology. The lab has extensive collaborations with international groups in bioinformatics, immunology and cancer biology. For details see https://jahnsenlab.org.
Applicants must hold a PhD degree in biology, immunology, or a related field. Prior knowledge of bioinformatics and/or organoid technology is considered an advantage
The candidate will work in a very ambitious interdisciplinary setting, which will require high flexibility. Fluent oral and written communication skills in English.
- An exciting research environment with opportunities for academic development.
- Salary NOK 550 000 to NOK 620000 per annum depending on qualifications.
- After 3 years there is a possibility of extension for a fourth year.
Oslo University Hospital is a highly specialized hospital in charge of extensive regional and local hospital assignments. As Scandinavia’s largest hospital, we carry out more than 1.2 million patient treatments each year. The hospital has a nationwide responsibility for a number of national and multi-regional assignments, and has several national centers of competence. Oslo University Hospital is responsible for approximately 50 percent of all medical and health care research conducted at Norwegian hospitals, and is a significant role player within the education of a large variety of health care personnel.
- Antall stillinger
- Sognsvannsveien 20, 0372 Oslo
- Forskning, utdanning og vitenskap
Postdoc, research, cancer, immunology, Pathology
|Sist endret||11. feb. 2022 13:38|