Utløpt

PhD candidate in mucosal immunology

Arbeidsgiver
Oslo universitetssykehus HF
Stillingstittel
PhD candidate
Frist
10.02.2022
Ansettelsesform
Engasjement
Bli kjent med Oslo universitetssykehus

We seek a motivated and enthusiastic co-worker for a 3-year PhD fellowship (with a possibility of extension) in our research group (https://jahnsenlab.org/). The position will primarily be based at the Department of Pathology, Oslo University Hospital/Rikshospitalet. 

Oslo University Hospital is a highly specialised hospital in charge of extensive regional and local hospital assignments and the provision of high quality services for the citizens of Oslo. The hospital also has a nationwide responsibility for a number of national and multi-regional assignments and has several national centres of competence.

 

About the position

The focus of our research is the regulation of the immune response in the human intestinal tract, both in health and disease. The aim of this project is to identify biomarkers that may predict treatment response in Crohn’s disease patients.
To understand the cellular networks associated with failure to reach durable remission upon anti-TNF therapy, we will take advantage of the most recent advances in experimental and computational methods and study the disease process in Crohn’s disease lesions: 1) Single-cell RNA sequencing (scRNAseq) of tissue-derived cells from inflamed and healthy intestine will give an unbiased characterization of the gene expression levels in all cells, and 2) Spatial Transcriptomics will reveal the spatial pattern of gene expression levels within the tissue.
Based on this analysis we will construct a single-cell gene expression atlas with spatial information across tissues from both treatment responders and non-responders. This will give a unique possibility to identify differences at the cellular and molecular level in time and space in the search for predictive biomarkers for treatment response.
The PhD candidate will be part of a dynamic and stimulating research environment within immunology, molecular biology, bioinformatics, clinical gastroenterology and an ongoing, observational inception cohort study of patients with suspected IBD (IBSEN III).
The fellowship period is three years and is funded by the Southern and Eastern Norway Regional Health Authority (HSØ). The PhD fellow must take part in the he PhD programme at the Faculty of Medicine, University of Oslo, and is expected to complete the project within the fellowship period.

For more information, please visit www.med.uio.no/english/research/phd/

Qualifications

The candidate must hold a Master’s degree in life sciences, computational analyses or similar – or is a physician/MD who has interest in translational research. The Master’s thesis and the average grade point for courses included in the Master’s degree must have the grade B or better.

Training will be provided, but previous experience with laboratory work within molecular biology and/or the R software environment is an advantage. Excellent written and verbal communication skills in English are a prerequisite. 

 

Personal qualities

  • Strong motivation
  • Excellent problem-solving skills
  • Ability to work independently and as an integrated member of a team
  • Good communication skills

We can offer

  • Excellent working conditions
  • An exciting and stimulating academic environment
  • Attractive welfare benefits and a generous pension agreement, in addition to Oslo’s family-friendly environment with its rich opportunities for culture and outdoor activities

How to apply

The application must include:
- Application letter, including motivation for applying for the position statement and research interests
- CV (summarizing education, positions and academic work)
- Copies of educational certificates and transcripts of records
- A complete list of publications and academic works
- Contact details of 2-3 references (name, relation to candidate, e-mail and phone number)

The application with attachments must be submitted through our electronic recruiting system (link). Foreign applicants are advised to attach an explanation of their University's grading system. Please note that all documents should be in English (or a Scandinavian language).
Applicants may be invited for an interview.

    Om arbeidsgiveren

    Oslo University Hospital is a highly specialized hospital in charge of extensive regional and local hospital assignments. As Scandinavia’s largest hospital, we carry out more than 1.2 million patient treatments each year. The hospital has a nationwide responsibility for a number of national and multi-regional assignments, and has several national centers of competence. Oslo University Hospital is responsible for approximately 50 percent of all medical and health care research conducted at Norwegian hospitals, and is a significant role player within the education of a large variety of health care personnel. 

    Sektor
    Offentlig
    Sted
    Sognsvannsveien 20, 0372 Oslo
    Bransje
    Helse og omsorg,
    Forskning, utdanning og vitenskap
    Stillingsfunksjon
    Forskning/Stipendiat/Postdoktor

    Nøkkelord

    phd, candidate, research, mucosal, immunology

    Spørsmål om stillingen

    Kontaktperson
    Espen Bækkevold
    Stillingstittel
    Researcher
    Kontaktperson
    Diana Domaska
    Stillingstittel
    Researcher
    Følg firma
    3312 følger dette firmaet

    Sognsvannsveien 20, 0372 Oslo

    Stort kart Hybridkart Flyfoto

    Annonseinformasjon

    FINN-kode 246396837
    Sist endret 28. jan. 2022 09:23

    Rapporter annonse