Utløpt

Research engineer in Immunomonitoring and Immunotherapy development

Arbeidsgiver: Oslo universitetssykehus HF
Stillingstittel: Research engineer
Frist: 09.01.2022
Ansettelsesform: Engasjement

We are looking for a highly motivated research technician/engineer to join our team at the Translational Research Unit, Section of Cellular therapy, Oslo University Hospital-Radium Hospital, Oslo, Norway. The section is home to one of Europe’s biggest and most modern GMP facilities for cellular products. The Unit is composed of 18 employees within a section that counts close to 40.
The focus of the Translational Research Unit is the development of new immunotherapy treatments for cancer. This includes the pre-clinical and clinical testing of enhanced cancer vaccines, adoptive T-cell therapy (TCR, CAR) and the improvement of cellular therapy for increased resistance to the microenvironment. After six years of activity, our results have generated numerous patent applications, the establishment of a biotech company (Zelluna Immunotherapy AS) and translation into a clinical protocol of T-cell therapy (NCT03431311).
This is a limited term appointment with funding for this post expected to be available for a period of 15 months from February 2022 in the first instance with the possibility of extension. The candidate will be under the supervision of Dr. Else Marit Inderberg (group leader).

For more information on the work of the group, please visit here: http://celltherapy.no/

Job description/Project description:

The successful candidate will integrate a collaborative international scientific team working on immunomonitoring in clinical trials and developing novel cancer immunotherapies.
The work entails culturing processing patient samples, isolating T cells, performing immunological assays including flow cytometry and mass cytometry, cytokine measurements, proliferation assays.
Furthermore, the candidate will contribute in pre-clinical projects by optimising T cell culture and engineering with immune receptors such as T cell receptors (TCR) and chimeric antigen receptors (CAR) as well as setting up potency assays to measure the efficacy of novel therapies.
The candidate will as all lab members be participating in lab duties such as cleaning and maintenance of the instruments/devices and will be responsible for certain tasks. Finally, the candidate will participate in an active program of scientific discussions through regular team meetings and collaborate with other research groups.

Qualifications:

Applicants must have a university degree (min. Master degree in science or equivalent experience). We are seeking candidates with strong experience in immunology and cell biology, specifically with experience in T cell culture and related assays (cytotoxic assays, cytokine detections, etc.) and documented experience with flow cytometry and knowledge in GLP and GMP procedures.
It is an advantage to be able to manipulate a flow cytometer independently (analysis and/or sorting) Knowledge in molecular biology, protein chemistry or bioinformatics will also be considered as valuable.
A good command of English (weekly lab meeting) and informatics are expected.
Some knowledge of Norwegian would be an advantage.

The application must include the following:

The application must include the following:
Application letter (1 page max)
CV (2 pages max, summarizing education, positions, and other qualifying activities)
Copies and transcripts of educational certificates and diplomas
Names and contact details of (min 1, max 3) references (name, relation to candidate, e-mail and telephone number)

Om arbeidsgiveren

Oslo University Hospital is a highly specialized hospital in charge of extensive regional and local hospital assignments. As Scandinavia’s largest hospital, we carry out more than 1.2 million patient treatments each year. The hospital has a nationwide responsibility for a number of national and multi-regional assignments, and has several national centers of competence. Oslo University Hospital is responsible for approximately 50 percent of all medical and health care research conducted at Norwegian hospitals, and is a significant role player within the education of a large variety of health care personnel.

Sektor: Offentlig
Sted: Ullernchausseen 64, 0379 Oslo
Bransje: Helse og omsorg
Stillingsfunksjon: Ingeniør