Two Postdoctoral Research Scientist positions
- Oslo universitetssykehus HF
- Postdoctoral researcher
We are looking for two highly motivated Postdoctoral researchers to join our team for 3 years at the Translational Research Unit (PIs: Dr. Sébastien Wälchli and Dr. Else Marit Inderberg), Section of Cellular therapy, Oslo University Hospital-Radium Hospital, Oslo, Norway. The Section is home to one of Europe’s biggest and most modern GMP facilities for cellular products. The Unit is composed of 18 employees within a department that counts close to 40.
The focus of the Translational Research Unit is the development of new immunotherapy treatments for cancer. This includes the pre-clinical and clinical testing of enhanced cancer vaccines, adoptive T-cell therapy (TCR, CAR) and the improvement of cellular therapy for increased resistance to the microenvironment. After six years of activity, our results have generated numerous patent applications, the establishment of a biotech company (Zelluna Immunotherapy AS) and translation into a clinical protocol of T-cell therapy (NCT03431311).
For more information on the work of our Unit, please visit here: http://celltherapy.no/
Job description/Project descriptionThe successful candidates will integrate a collaborative international scientific team developing novel cancer immunotherapies. The project funded by the Research Council of Norway is carried out in collaboration with SINTEF, Thermo Fisher and Oslo Cancer Cluster, aiming to define optimal growth conditions for improved manufacturing of therapeutically active T cells for cancer treatment.
We offer a position in a dynamic environment within a modern (2015) and fully equipped facility. The project is oriented towards translational research and process development, and the candidate will therefore be in contact with academic and industry partners. Project partner SINTEF provides extensive infrastructure for high-throughput screening and bioprocess development (including liquid handlings robots, microbioreactor systems), that will be utilized to evaluate cell therapy growth conditions. Occasional travelling and stays at the site of SINTEF in Trondheim will be expected. In addition, the candidate will be encouraged to participate in at least one international conference per year where he/she will present his/her data.
Only highly motivated candidates should apply for this position. He/she should be able to both work independently and be strong team player. He/she should fulfil the following criteria:
- PhD or other corresponding education equivalent to a Norwegian doctoral degree
- We are seeking candidates with a background in bioinformatics, biotechnology and cellular biology background orientated towards immunology/immunotherapy.
- All candidates (except bioinformaticians) should have documented previous experience with primary cell culture, preferentially lymphocytes. It will be considered an advantage to have experience with viral transduction and/or previous work with CAR or TCR. Bioinformaticians should have documented experience in analysing cell phenotypes (TCR/antibody sequences) and cancer patient data.
- The candidate should possess strong experience in at least one of these technologies (to be documented via certificate or scientific publications): mastering advanced flow cytometry (multi-parameter) and/or CyTOF, cytokine measurements (BioPLEX or similar devices), cellular metabolism (Seahorse or similar devices), cytotoxicity assays (Flow-based, BLI), 3D structure generation (spheroids, organoids), advanced live cell microscopy (fluorescent microscopy, Incucyte or similar devices).
- It will be considered as an advantage to have prior experience with drug development, anti-tumor cellular immune response studies, bioprocess development.
A good command of English and informatics tools are expected and ability to independently write scientific articles will be required
. The application must include the following
- Application letter (1 page max)
- CV (2 pages max, summarizing education, previous positions, list of publications, and other qualifying activities)
- Copies and transcripts of educational certificates and diplomas
- Names and contact details of (min 1, max 3) references
Oslo University Hospital is a highly specialized hospital in charge of extensive regional and local hospital assignments. As Scandinavia’s largest hospital, we carry out more than 1.2 million patient treatments each year. The hospital has a nationwide responsibility for a number of national and multi-regional assignments, and has several national centers of competence. Oslo University Hospital is responsible for approximately 50 percent of all medical and health care research conducted at Norwegian hospitals, and is a significant role player within the education of a large variety of health care personnel.
- Antall stillinger
- Ullernchausseen 64, 0379 Oslo
- Helse og omsorg,
- Forskning, utdanning og vitenskap
|Sist endret||16. des. 2021 15:15|