Utløpt

Post-doc

Arbeidsgiver
Oslo universitetssykehus HF
Stillingstittel
Post-doc
Frist
21.05.2021
Ansettelsesform
Engasjement
Bli kjent med Oslo universitetssykehus
A post-doc position is available in the Cancer Molecular Medicine group of Dr. Enserink at the Institute for Cancer Research at the Division for Cancer Medicine from July 01, 2021 for 3 years (the start date can be negotiated, but preferably no later than September 01, 2021).
 
The organization and research focus  The Cancer Molecular Medicine group is located at the Radium hospital, which is part of Oslo University Hospital, the largest academic hospital in Scandinavia. The group is a member of a Norwegian Centre of Excellence (Centre for Cancer Cell Reprogramming, CanCell), which consists of six research groups focused on unraveling molecular mechanisms of tumorigenesis.
 
One of the main research aims of the group is to better understand the cellular response to nutrient starvation, particularly autophagy. Autophagy is a powerful catabolic process that must be carefully regulated, because uncontrolled autophagy can result in severe fitness defects. Although much is known about the core autophagy machinery, it remains poorly understood how the cell regulates the kinetics of this process under fluctuating nutrient conditions at a systems level.
During the past years we have determined the effect of nearly every gene in the budding yeast genome on autophagy kinetics. These unpublished findings suggest the existence of a network of intricate feedback loops and adaptive mechanisms that control commitment to autophagy and that fine-tune autophagic input during nutrient starvation. The vast amount of unpublished data are a treasure trove for multiple exciting new projects, and while this project will mainly focus on unraveling upstream regulatory pathways that control the commitment to autophagy and suppression of noise in the autophagy pathway, the successful candidate will have the opportunity to explore additional research interests.

Job description:

  • The candidate will develop novel fluorescent autophagy reporters to study noise suppression and analyze upstream activity of the autophagy pathway in budding yeast. These reporters will be used to analyze commitment and noise suppression in a selection of mutants that will be selected from our genome-wide dataset.
  • Methods: The project will primarily involve cloning, genetic manipulation of yeast, live-cell fluorescence microscopy and mathematics/bioinformatics.

Requirements:

  • We are looking for a talented, enthusiastic and determined person who can work both independently as well as in the context of a team.
  • Potential candidates have completed (or are very close to completing) a PhD degree in biology.
  • The successful candidate is positive-minded, is looking forward to learning new techniques, has good communication skills and is well organized.
  • Experience with fluorescence microscopy and molecular biology are essential requirements.

In-depth knowledge of either autophagy, yeast genetics, bioinformatics/mathematics (machine learning, neural networks) or analysis of fluorescence images/movies will be advantageous.

Interested persons should submit the following documents:
A concise application letter (1-2 pages) describing why you are the best candidate for this position.
Curriculum vitae, including a list of publications.
Two reference letters, including contact information of all the references (email address, postal address, phone number and relation to candidate).      
Please note that applications lacking any of these three requirements will be discarded automatically.

Foreign applicants are advised to attach an explanation of their University's grading system.
Please note that all documents should be in English (or a Scandinavian language).
In assessing the applications, special emphasis will be placed on the documented academic qualifications, as well as the candidate’s motivation and personal suitability. Interviews with the best qualified candidates will be arranged.
It is expected that the successful candidate will be able to complete the project in the course of the period of employment.  

Personal qualities:

  • Good command of English, team player, well organized, flexible, positive attitude.

We offer:

  • A positive-minded, international research environment with a wide variety of methods, offering the possibility to learn new methods and techniques, support from state of the art core facilities, career coaching, and assistance with grant writing.
  • Access to  an excellent, international research network via our Centre of Excellence.

Om arbeidsgiveren

Sammen med pasienten utvikler vi morgendagens behandling

Oslo universitetssykehus med våre 22 000 ansatte skal være en lærende og skapende organisasjon med evne til å tenke nytt. Vi skal ha en ledende rolle i utvikling av forskning og innovasjon, samt utvikling av morgendagens helsetjeneste, medisinsk behandling og presisjonsmedisin. Hos oss finner du noen av landets ledende eksperter innen sine fagfelt, og her blir du en del av Norges største helsefaglige arbeidsplass. Et inkluderende arbeidsmiljø preget av åpenhet og respekt er svært viktig for oss. Uansett hva du jobber med vil du få muligheten til å utvikle deg og benytte din kompetanse på et sted hvor det virkelig teller.

Sektor
Offentlig
Sted
Ullernchausseen 70, 0379 Oslo

Nøkkelord

Post-doc,, cell, cancer, research, kreftforskning

Spørsmål om stillingen

Kontaktperson
Jorrit Enserink
Stillingstittel
Enhetsleder
Telefon
95 00 56 41
Følg firma
4269 følger dette firmaet

Ullernchausseen 70, 0379 Oslo

Annonseinformasjon

FINN-kode 215185729
Sist endret 16. apr. 2021 15:33

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