Utløpt

Post doctor

Arbeidsgiver: Oslo universitetssykehus HF
Stillingstittel: Postdoktor
Frist: 05.04.2021
Ansettelsesform: Engasjement

A post-doc position is available in the Cancer Molecular Medicine group of Dr. Enserink at the Institute for Cancer Research at the Division for Cancer Medicine from June 01, 2021 for 3 years (the exact start date can be negotiated).

The organization and research focus
The Cancer Molecular Medicine group is located at the Radium hospital, which is part of Oslo University Hospital, the largest academic hospital in Scandinavia. The group is a member of a Norwegian Centre of Excellence (Centre for Cancer Cell Reprogramming, CanCell), which consists of six research groups focused on unraveling molecular mechanisms of tumorigenesis. One of the main research aims of the group is to better understand the cellular response to nutrient starvation, particularly autophagy. Autophagy is a powerful catabolic process that must be carefully regulated, because uncontrolled autophagy can result in severe fitness defects. Although much is known about the core autophagy machinery, it remains poorly understood how the cell regulates the kinetics of this process under fluctuating nutrient conditions.
During the past years we have determined the effect of nearly every gene in the budding yeast genome on autophagy kinetics. These unpublished findings suggest the existence of intricate feedback loops and adaptive mechanisms that control commitment to autophagy and that fine-tune autophagic input during nutrient starvation. This project will focus on unraveling these regulatory pathways with particular focus on commitment and noise suppression.

Work tasks

The candidate will develop novel fluorescent autophagy reporters to study noise suppression and analyze upstream activity of the autophagy pathway in budding yeast. These reporters will be used to analyze commitment and noise suppression in a selection of mutants that will be selected from our genome-wide dataset.
The project will primarily involve cloning, genetic manipulation of yeast, advanced live-cell fluorescence microscopy and mathematics/bioinformatics.

Kvalifikasjoner

We are looking for a talented, enthusiastic and determined person who can work both independently as well as in the context of a team.
Potential candidates have completed (or are very close to completing) a PhD degree in biology.
The successful candidate is positive-minded, is looking forward to learning new techniques, has good communication skills and is well organized.
Experience with live-cell fluorescence microscopy and molecular biology are essential requirements.
In-depth knowledge of autophagy, yeast genetics, bioinformatics/mathematics (machine learning, neural networks) and analysis of fluorescence images/movies is a strong advantage.

How to apply:
Interested persons should submit the following documents to Webcruiter:
(note that applications lacking any of these three requirements will be discarded automatically, and only applications in Webcruiter will be evaluated):

A concise application letter (1-2 pages) describing why you are the best candidate for this position.
Curriculum vitae, including a list of publications.

Three reference letters, including contact information of all the references (email address, postal address, phone number and relation to candidate).

Preferred start date: June 01, 2021 (start date is negotiable).

The application with attachments must be delivered in our electronic recruiting system, please follow the link “apply for this job”.
Foreign applicants are advised to attach an explanation of their University's grading system.
Please note that all documents should be in English (or a Scandinavian language).
In assessing the applications, special emphasis will be placed on the documented academic qualifications, as well as the candidate’s motivation and personal suitability. Interviews with the best qualified candidates will be arranged.
It is expected that the successful candidate will be able to complete the project in the course of the period of employment.

Personal skills

High work capacity and productivity
Able to work independently and in teams
Motivated and solution oriented
Multidisciplinary communication skills
Commitment to meeting deadline

We offer

A professional, stimulating working environment
Salary according to qualifications
Favorable pension arrangements
Attractive welfare benefits
Temporary engagement with the possibility of extension.

Om arbeidsgiveren

Developing tomorrow's treatment - together with the patient.

Oslo University Hospital with 22 000 employees is a learning and forward-thinking organization. We have a leading role in the development of research and innovation, as well as the development of tomorrow's healthcare, precision medicine and treatment. Here you will find some of Norway's leading experts in their fields, and be part of the largest health care workplace in the country. Our work environment is characterized by openness and respect. Regardless of educational background or experience, you will have the opportunity to develop and use your expertise in a place where it really matters.

Sektor: Offentlig
Sted: Ullernchausseen 70, 0379 Oslo