Position as bioinformatician (spesialingeniør)
Oslo universitetssykehus HF
- Frist 20.9.2020
- Ansettelsesform Fast
Bioinformatician - Specialengineer
Help us discover patterns in genomic data and improve patient diagnostics
High-throughput sequencing (HTS) is a technology that allows for fast and cost-effective characterization of DNA. Department of Medical Genetics at OUS is Norway's largest medical genetics department with over 240 employees and state-of-the-art sequencing equipment. We are continuing to expand our diagnostic offering based on HTS and are looking for a bioinformatician to develop genomics analyses that can help the diagnosis of patients suffering from severe, hereditary diseases, ranging from the ultra-rare to common heart conditions and cancer.
The Unit for HTS-diagnostics drive the development of new diagnostic analysis pipelines as well as software and methodologies that provide decision support, in particular for genetic variant interpretation. We are a diverse, multi-disciplinary team of bioinformaticians, developers, molecular biologists and mathematicians seeking candidates who can contribute their experience and talent to further develop bioinformatics at OUS. As part of our team, you will work in a fast-evolving field that constantly presents new challenges and possibilities. Our goals for the near future include extending the diagnostic toolkit to all types of structural variants and variants in mitochondrial DNA, use of phenotype ontologies, and further developing the open-source application ELLA, with an overarching goal of putting OUS at the forefront of precision medicine as the field develops. In addition to diagnostic work, our group also collaborates with commercial and academic partners in research and innovation projects (e.g. BigMed.no).
The position is full-time and permanent. For more background information and details, please see the description of the research part of our group at https://www.ous-research.no/digigen/ and http://about.ousamg.io/ Please contact group coordinator Tony Håndstad at tony.handstad@medisin.uio.no (+47 906 09 379) or unit manager Knut Erik Berge at kberge@ous-hf.no for any questions. The deadline for applications is September 20th. Note that the full suitability of a candidate will be given consideration in the selection and interview process.
Responsibilities:
- Analyse variant interpretation data, and in an interdisciplinary collaboration with molecular biologists, lab doctors and other bioinformaticians, recommend how to scale the interpretation process and improve diagnostic quality.
- Develop rules and models that provide decision support for novel types of variants and medical contexts, for example mitochondrial, structural, and somatic variants, and with extended use of phenotype data.
- Develop pipelines for variant calling and annotation, perform quality control and create reports and documentation of analyses.
- Develop modules for bioinformatical analyses, integrate new tools and data into our systems and automate flow and management of large data volumes.
- Contribute to data analyses in our diagnostic production in general, and take part in forming projects that further our research arm in the areas of variant interpretation and genomic data sharing.
Qualifications
- Higher education in bioinformatics, informatics, statistics or similar disciplines. A PhD degree, previous experience within bioinformatics and knowledge of genetics and/or molecular biology is an advantage.
- Experience with quantitative analysis and visualization. Practical experience with HPC, large data volumes and common data science and ML frameworks is beneficial.
- Good programming skills (Python) and proficiency with Linux/CLI, preferably also with basic DevOps like git, Docker, CI, etc.
- Self-motivated to learn and perform, able to work in a structured manner with a high attention to details.
- Excellent English communication skills. Experience with planning research projects is beneficial.
Personal qualifications
- Self-motivated to learn and perform, able to work in a structured manner with a high attention to details.
- Excellent English communication skills. Experience with planning research projects is beneficial.
- Meet deadlines and demonstrate problem solving skills.
We can offer
- Work in an exciting and extremely fast-developing field with a high impact on healthcare.
- Varied tasks, and autonomy to exercise and develop a wide range of skills.
- Opportunity to initiate and/or take part in research projects in-between main activities.
- Flexible hours with possibilities for part-time remote work.
- Highly competent and friendly colleagues to learn from.
- Salary dependent on qualifications.
Om arbeidsgiveren
Oslo University Hospital is a highly specialized hospital in charge of extensive regional and local hospital assignments. As Scandinavia's largest hospital, we carry out more than 1.2 million patient treatments each year. The hospital has a nationwide responsibility for a number of national and multi-regional assignments, and has several national centers of competence. Oslo University Hospital is responsible for approximately 50 percent of all medical and health care research conducted at Norwegian hospitals, and is a significant role player within the education of a large variety of health care personnel.
- Sektor: Offentlig
- Sted: Kirkeveien 166, 0450 Oslo
- Bransje: Forskning, utdanning og vitenskap, Helse og omsorg, IT
- Stillingsfunksjon: Utvikler (generell)
Nøkkelord
bioinformatics, bioinformatikk, machine, learning, genetics
- FINN-kode 189394164
- Sist endret