Postdoctoral Research fellow in Alzheimer's disease, mitophagy, and aging
- Arbeidsgiver
- Akershus universitetssykehus HF
- Stillingstittel
- Postdoctoral Research fellow in Alzheimer's disease, mitophagy, and aging
- Frist
- 31.10.2017
- Ansettelsesform
- Engasjement
This is a unique opportunity for a driven, highly self-motivated and talented Postdoctoral Research fellow to join a research group of Dr. Evandro F. Fang at the Akershus University Hospital to investigate the molecular and cellular mechanisms underlying human aging and agerelated neurodegeneration.
We are seeking a Postdoctoral Research Fellow who will be based in the Section of Clinical Molecular Biology, Akershus University Hospital and will collaborate closely with Prof. Hilde Nilsen (University of Oslo), and colleagues in National Institute on Aging, NIH (USA), University of Oxford (UK), and University of Crete (Greece). You will be part of a team investigating the molecular mechanisms of mitochondrial autophagy (mitophagy) and its roles in neurodegeneration, especially Alzheimer's disease, and aging.
This post is fixed-term for up to 3~4 years.
Several aging-related projects are being developed in the Fang laboratory, including 1) molecular mechanisms of mitophagy; 2) mitochondrial dysfunction and compromised mitophagy in neurodegeneration; and 3) NAD+ and aging. The laboratory has longstanding interests to address the molecular mechanisms of these questions using crossspecies laboratory models, including human iPCSs, C. elegans, mice, and human samples. You will be involved in developing one project with other duties/opportunities include writing and collaborating on papers for high-profile journal publications and attending and presenting at national/international conferences.
You will hold a relevant PhD (or related degree) together solid experience biochemistry and neuroscience. Candidates with strong experience in C. elegans research are preferable. You are expected to have good publication records and the ability to work accurately, keep good records and work as part of a team are essential for this position.
To apply for this role and for further details, please send your latest CV and "Research Proposal" (1~2 pages). Qualified candidates will be further asked to solicit two-three recommendation letters.
The postdoc positions are open until filled. Prospective candidates are encouraged to apply as soon as possible and interviews are likely to take place shortly.
Applicants will have to apply electronically.
Deadline for application: 31.10.2017
Additional information:
The Department of Clinical Molecular Biology is located at Akershus University Hospital where it is a part of the Division of Medicine and Laboratory Sciences. The Department has a large and well-equipped molecular biology laboratory that enables advanced translational research. Research themes include: Genome Stability, Cancer Genomics and Cancer Biology, Neurological diseases
(http://www.med.uio.no/klinmed/english/about/organization/divisions/medicinelaboratory-sciences/clinical-molecular-biology/)
References:
1. Kerr JS, Adriaanse BA, Greig NH, Mattson MP, Cader MZ, Bohr VA, Fang EF.
Mitophagy and Alzheimer's disease: Cellular and molecular mechanisms, Trends in
Neurosciences, 40(3):151-166.
2. Fang EF, Lautrup S, Hou Y, Demarest TG, Croteau DL, Mattson MP, Bohr VA. NAD+ in
aging: Molecular mechanisms and translational implicationis. Trends Mol Med. 2017.
(Feature review), in press.
3. Fang EF, Scheibye-Knudsen M, Brace L, Kassahun H, SenGupta T, Nilsen H, Mitchell
JR, Croteau DL, Bohr VA (2014). Defective Mitophagy in XPA via PARP1 hyperactivation
and NAD+/SIRT1 reduction, Cell, 157 (4): 882-896.
4. Fang EF, Kassahun H, Croteau DL, Scheibye-Knudsen M, Marosi K, Lu H, Shamanna
RA, Kalyanasundaram S, Bollineni RC, Wilson MA, Iser WB, Wollman BN, Morevati M,
Li J, Kerr JS, Lu Q, Waltz TB, Tian J, Sinclair DA, Mattson MP, Nilsen H, Bohr VA. NAD+
replenishment improves lifespan and healthspan in Ataxia telangiectasia models via
mitophagy and DNA repair, Cell Metabolism, 2016.
5. Fang EF, Scheibye-Knudsen M, Chua KF, Mattson MP, Croteau DL, Bohr VA (2016).
Nuclear DNA damage signalling to mitochondria in ageing, Nature Rev Mol Cell Bio,
17(5):308-321.
Om arbeidsgiveren
Akershus University Hospital is the largest acute hospital in Norway, and local and area hospital for close to 10% of the Norwegian population. We have a fast growing research environment in the field of medicine and health sciences. Akershus University Hospital aims for our work force to reflect our values of multi-disciplinarity, diversity and equality. We therefore seek a balance in the age and gender profile of our staff, and we are particularly interested in recruiting people from ethnic minorities.
- Sektor
- Offentlig
- Sted
- Sykehusveien 25, 1478 Lørenskog
- Bransje
- Helse og omsorg
- Stillingsfunksjon
- Annet
Nøkkelord
Oslo, Akershus, Postdoctoral, Research